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In general, psilocybin causes changes in mood, changes in thought-pattern, and, at higher doses, hallucinations. Less-enjoyable effects commonly include excessive yawning, nausea, and sometimes even vomiting. Severe reactions, such as convulsions, are very rare, but they can occur. Psilocybin has shown medicinal potential, and many people use mushrooms to self-treat a wide variety of conditions, from migraine headaches to anxiety. Unfortunately, the scientific research on these claims is still in its infancy, in part because of the legal barriers to clinical study.
“Mood changes” mean, ideally, euphoria and a feeling of connectedness, though some people instead experience anxiety—which can be intense and disturbing. Some users explain the radically different possible effects by saying that psilocybin simply enhances whatever the user was already feeling. This is one reason why proper mental preparation for the experience, together with a safe and enjoyable setting, are so important
“Changes in thought-pattern” often includes personal and spiritual insight.
Burma mushrooms[ii] are generally said to produce an intense and enjoyable experience, but with little of the insight encouraged by other strains.